This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

This volume provides a balanced set of reviews which introduce the central topics in the philosophy of time. This is the first introductory anthology on the subject to appear for many years; the contributors are distinguished, and two of the essays are specially written for this collection. In their introduction, the editors summarize the background to the debate, and show the relevance of issues in the philosophy of time for other branches of philosophy and for science. Contributors include J.M.E. McTaggart, (...) Arthur N. Prior, D.H. Mellor, Sydney Shoemaker, Graeme Forbes, Lawrence Sklar, Michael Dummett, David Lewis, W.H. Newton-Smith, and Anthony Quinton. (shrink)

Thus, Meyers provides a valuable account, not only of current medical attitudes, but also of relevant case and statute law as it stands at present.

Kenneth Goodpaster has criticized ethicists like Feinberg and Frankena for too narrowly circumscribing the range of moral considerability, urging instead that “nothing short of the condition of being alive” is a satisfactory criterion. Goodpaster overlooks at least one crucial objection: that his own “condition of being alive” may aIso be too narrow a criterion of moral considerability, since “being in existence” is at least as plausible and nonarbitrary a criterion as is Goodpaster’s. I show that each of the arguments that (...) Goodpaster musters in support of his criterion can be used equally weIl to bolster “being in existence” as a test of moral considerability. Moreover, I argue that “being in existence” appears to be a stronger criterion overall, since it is broader. Until or unless a fuller justification is forthcoming of “being alive” as a satisfactory criterion of moral considerability-a justification which must demonstrate that “mere things,” included under the condition of “being in existence,” do not deserve moral consideration--Goodpaster’sthesis is confronted with a serious problem. (shrink)

David Miller elegantly and provocatively reformulates critical rationalism—the revolutionary approach to epistemology advocated by Karl Popper—by answering its most important critics. He argues for an approach to rationality freed from the debilitating authoritarian dependence on reasons and justification. "Miller presents a particularly useful and stimulating account of critical rationalism. His work is both interesting and controversial... of interest to anyone with concerns in epistemology or the philosophy of science." —Canadian Philosophical Reviews.

David Miller is the foremost exponent of the purist critical rationalist doctrine and here presents his mature views, discussing the role that logic and argument play in the growth of knowledge, criticizing the common understanding of argument as an instrument of justification, persuasion or discovery and instead advocating the critical rationalist view that only criticism matters. Miller patiently and thoroughly undoes the damage done by those writers who attack critical rationalism by invoking the sterile mythology of induction and justification (...) that it seeks to sweep away. In addition his new material on the debate on verisimilitude is essential reading for all working in this field. (shrink)

This paper articulates and defends a noncognitive, care-based view of identification, of what privileged psychic subset provides the source of self-determination in actions and attitudes. The author provides an extended analysis of "caring," and then applies it to debates between Frankfurtians, on the one hand, and Watsonians, on the other, about the nature of identification, then defends the view against objections.

Many philosophers have taken there to be an important relation between personal identity and several of our practical concerns (among them moral responsibility, compensation, and self-concern). I articulate four natural methodological assumptions made by those wanting to construct a theory of the relation between identity and practical concerns, and I point out powerful objections to each assumption, objections constituting serious methodological obstacles to the overall project. I then attempt to offer replies to each general objection in a way that leaves (...) the project intact, albeit significantly changed. Perhaps the most important change stems from the recognition that the practical concerns motivating investigation into personal identity turn out to be not univocal, as is typically thought, such that each of the different practical concerns may actually be related to personal identity in very different ways. (shrink)

In lieu of an abstract, here is the first paragraph: Paksi and Héder’s Guide to Personal Knowledge (hereafter GPK and Guide) is, as the title suggests, a guide of the most important and original ideas of Michael Polanyi’s book Personal Knowledge: Towards a Post-Critical Philosophy (1958, hereafter PK). Is a guide to Personal Knowledge needed? I think the answer is a resounding “yes” for many new readers. To see why, let’s briefly review two common complaints about PK.

In this paper, I attempt to show that the moral/conventional distinction simply cannot bear the sort of weight many theorists have placed on it for determining the moral and criminal responsibility of psychopaths. After revealing the fractured nature of the distinction, I go on to suggest how one aspect of it may remain relevant—in a way that has previously been unappreciated—to discussions of the responsibility of psychopaths. In particular, after offering an alternative explanation of the available data on psychopaths and (...) their judgments of various sorts of norm transgressions, I put forward a hybrid theory of their responsibility, suggesting how they might be criminally responsible, while nevertheless failing to meet the conditions for an important arena of moral responsibility. (shrink)

[Open access] In this book symposium the author takes up questions from phenomenology, hermeneutics, ethical theory, and intellectual history raised by a group of scholarly interlocutors from a range of backgrounds. In the course of engaging with these issues, he discusses, inter alia, McDowell’s realism, Jonathon Lear’s work on the end of a world, Michael Oakeshott’s view of selfhood, Heidegger’s conception of Jemeinigkeit, Uexküll’s notion of Umwelt, and Gadamer’s hermeneutic conception of truth.

Take a hypothetical sequence of human beings ordered by height from tallest to shortest. Make sure there is no more than a difference of a millimeter between each person and make sure the tallest person is clearly tall and the shortest person is clearly not tall. Now consider the following argument: P1 A person of height n is tall ; P2 For any height n, if n is tall, then n–1mm is tall ; C Therefore, a person of height n (...) = 1mm is tall. P1 and P2 are intuitively true, C is intuitively false, yet the argument is deductively valid (the conclusion follows... (shrink)

Brimming with visual examples of concepts, derivation rules, and proof strategies, this introductory text is ideal for students with no previous experience in logic. Students will learn translation both from formal language into English and from English into formal language; how to use truth trees and truth tables to test propositions for logical properties; and how to construct and strategically use derivation rules in proofs.

"In the first study of its kind, David W. Johnson's "Watsuji on Nature" reconstructs the astonishing philosophy of nature of Watsuji Tetsurō (1889-1960), situating it in relation both to his reception of the thought of Heidegger and to his renewal of core ontological positions in classical Confucian and Buddhist philosophy. Johnson shows that for Watsuji we have our being in the lived experience of nature, one in which nature and culture compose a tightly interwoven texture called "fūdo". By fully (...) unfolding Watsuji's novel and radical claim that this is a setting that is neither fully external to human subjectivity nor merely a product of it, this book also sets out what still remains unthought in this concept, as well as in the relational structure that underwrites it. Johnson argues that what remains unarticulated is nothing less than the recovery of a reenchanted conception of nature and an elucidation of the wide-ranging implications of a relational conception of the self for questions about the disclosive character of experience, the distinction between fact and value, and the possibility of a place-based ecological ethics. In an engagingly lucid and deft analysis, "Watsuji on Nature" radically expands our appreciation of twentieth-century Japanese philosophy and shows what it has to offer to a global philosophical conversation"--Provided by publisher. (shrink)

In our age of globalization, we need a theory of global management consistent with our common human nature. The place to begin in developing such a theory is the philosophy of traditional cultures. The article focuses on African philosophy and its fruitfulness for contributing to a theory of management consistent with African traditional cultures. It also looks briefly at the Confucian and Platonic-Aristotelian traditions and notes points of agreement with African traditions. It concludes that the needed theory of global management (...) should regard the firm as a community, not a collection of individuals, and should understand the purpose of management as promoting the common good. (shrink)

Attacks nothing less than the currently prevailing worldphilosophy--humanism, which the author feels is exceedingly dangerous in itshidden assumptions.

Evolution is frequently concentrated in bursts of rapid morphological change and speciation followed by long‐term stasis. We propose that this pattern of punctuated equilibria results from an evolutionary tug‐of‐war between host genomes and transposable elements (TEs) mediated through the epigenome. According to this hypothesis, epigenetic regulatory mechanisms (RNA interference, DNA methylation and histone modifications) maintain stasis by suppressing TE mobilization. However, physiological stress, induced by climate change or invasion of new habitats, disrupts epigenetic regulation and unleashes TEs. With their capacity (...) to drive non‐adaptive host evolution, mobilized TEs can restructure the genome and displace populations from adaptive peaks, thus providing an escape from stasis and generating genetic innovations required for rapid diversification. This “epi‐transposon hypothesis” can not only explain macroevolutionary tempo and mode, but may also resolve other long‐standing controversies, such as Wright's shifting balance theory, Mayr's peripheral isolates model, and McClintock's view of genome restructuring as an adaptive response to challenge. (shrink)

David Hume's writings on history, politics and philosophy have shaped thought to this day. His bold scepticism ranged from common notions of the 'self' to criticism of standard theistic proofs. He insisted on grounding understandings of popular religious beliefs in human psychology rather than divine revelation, and he aimed to disentangle philosophy from religion in order to allow the former to pursue its own ends. In this book, Professors David W Purdie and Peter S Fosl decipher some of (...) Hume's most challenging texts for the modern reader, while preserving the sharp intellect and undaunted nerve for which Hume is famous. Hume's spirit is brought alive for contemporary times and his writing is made accessible for its intended audience: the general public."-- Back cover. (shrink)

This paper attempts to reconcile two ideas that seem fundamentally opposed to one another: the reality of the self and the doctrine of no-self. Buddhism offers a form of spiritual equanimity that turns on the denial of a self. Nonetheless, there seem to be good reasons to hold onto the reality of the self. The existence of a self enables us to account for praise and blame, the hopes for oneself that motivate actions, and attachments to the selves of others (...) in bonds of love and affection. I show how it may be possible to reconcile the reality of the self with a particular interpretation of the no-self doctrine by engaging with the work of thinkers from the phenomenological tradition such as Merleau-Ponty, Zahavi, Gallagher, and Petitmengin. (shrink)

Historically, nonclassical physics developed in three stages. First came a collection of ad hoc assumptions and then a cookbook of equations known as "quantum mechanics". The equations and their philosophical underpinnings were then collected into a model based on the mathematics of Hilbert space. From the Hilbert space model came the abstaction of "quantum logics". This book explores all three stages, but not in historical order. Instead, in an effort to illustrate how physics and abstract mathematics influence each other we (...) hop back and forth between a purely mathematical development of Hilbert space, and a physically motivated definition of a logic, partially linking the two throughout, and then bringing them together at the deepest level in the last two chapters. This book should be accessible to undergraduate and beginning graduate students in both mathematics and physics. The only strict prerequisites are calculus and linear algebra, but the level of mathematical sophistication assumes at least one or two intermediate courses, for example in mathematical analysis or advanced calculus. No background in physics is assumed. (shrink)

In this paper we study abstract elementary classes using infinitary logics and prove a number of results relating them. For example, if is an a.e.c. with Löwenheim–Skolem number κ then is closed under L∞,κ+-elementary equivalence. If κ=ω and has finite character then is closed under L∞,ω-elementary equivalence. Analogous results are established for . Galois types, saturation, and categoricity are also studied. We prove, for example, that if is finitary and λ-categorical for some infinite λ then there is some σLω1,ω such (...) that and contain precisely the same models of cardinality at least λ. (shrink)

The interest in and enthusiasm for urban agriculture (UA) in urban communities, the non-profit sector, and governmental institutions has grown exponentially over the past decade. Part of the appeal of UA is its potential to improve the civic health of a community, advancing what some call food democracy. Yet despite the increasing presence of the language of civic agriculture or food democracy, UA organizations and practitioners often still focus on practical, shorter-term projects in an effort both to increase local involvement (...) and to attract funding from groups focused on quantifiable deliverables. As such, it seems difficult to move beyond the rhetoric of food democracy towards significant forms of popular participation and deliberation within particular communities. In this paper we provide a theoretical framework—deep democracy—that helps to contextualize nascent attempts at civic agriculture or food democracy within a broader struggle for democratic practices and relationships. We argue that urban agriculture efforts are well positioned to help citizens cultivate lasting relationships across lines of difference and amidst significant power differentials—relationships that could form the basis of a community’s collective capacity to shape its future. We analyze the theory of deep democracy through recent experiences with UA in Denver, Colorado, and we identify ways in which UA can extend its reach and impact by focusing more consciously on its political or civic potential. (shrink)

This paper argues that explicit reading instruction should be part of lower level undergraduate philosophy courses. Specifically, the paper makes the claim that it is necessary to provide the student with both the relevant background knowledge about a philosophical work and certain metacognitive skills (e.g. their ability to reflect on the learning process) that enrich the reading process and their ability to organize the content of a philosophical text with other aspects of knowledge. A “How to Read Philosophy” handout and (...) student reactions to the handout are provided. (shrink)

In birds and frogs, species pairs retain the capacity to produce viable hybrids for tens of millions of years, an order of magnitude longer than mammals. What accounts for these differences in relative rates of pre- and postzygotic isolation? We propose that reproductive mode is a critically important but previously overlooked factor in the speciation process. Viviparity creates a post-fertilization arena for genomic conflicts absent in egg-laying species. With viviparity, conflict can arise between: mothers and embryos; sibling embryos in the (...) womb, and maternal and paternal genomes within individual embryos. Such intra- and intergenomic conflicts result in perpetual antagonistic coevolution, thereby accelerating interpopulation postzygotic isolation. In addition, by generating intrapopulation genetic incompatibility, viviparity-driven conflict favors polyandry and limits the potential for precopulatory divergence. Mammalian diversification is characterized by rapid evolution of incompatible feto-maternal interactions, asymmetrical postzygotic isolation, disproportionate effects of genomically-imprinted genes, and “F2 hybrid enhancement.” The viviparity-driven conflict hypothesis provides a parsimonious explanation for these patterns in mammalian evolution. BioEssays 22:938–946, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Using the example of a beginning teacher’s account of the experience of entering her new school for the first time, this paper presents a consideration of the nature of interpetive inquiry in education and how such inquiry treats ‘the individual case’. This is compared with how more traditional, quantitative studies might treat such cases. The pedagogic character of interpretive inquiry is then discussed.

This paper defends the permissibility of stem cell research against a theological objector who objects to it by appealing to "souls.".

Derek Parfit claims that, at certain times and places, the metaphysical units he labels *'selves" may be thought of as the morally significant units (I.e., the objects of moral concern) for such things as resource distribution, moral responsibility, commitments, etc. But his concept of the self is problematic in important respects, and it remains unclear just why and how this entity should count as a moral unit in the first place. In developing a view I call *'Moderate Reductionism," I attempt (...) to resolve these worries, first by offering a clearer, more consistent account of what the concept of *'self ' should involve, and second by arguing for why selves should indeed be viewed as moral (and prudential) units. I then defend this view in detail from both *'conservative" and *'extreme" objections. (shrink)

Cooperative learning processes have been rediscovered and are being used throughout the country on every level. The basic elements of cooperative goal structure are positive interdependence, individual accountability, face-to-face interaction, and cooperative skills. The teacher's role in structuring cooperative learning situations involves clearly specifying lesson objectives, placing students in productive learning groups and providing appropriate materials, clearly explaining the cooperative goal structure, monitoring students, and evaluating performance. For cooperative learning groups to be productive, students must be able to engage in (...) the needed collaborative skills. Cooperative skills and academic skills can be taught simultaneously. The implementation of cooperative learning needs to be coupled with the implementation of collaborative professional support groups among educators. Both the success of implementation efforts and the quality of life within most schools depend on teachers and other staff members cooperating with each other. Support for the program takes as careful structuring and monitoring as does cooperative learning. (JD). (shrink)

Agricultural decision making is characterized by two challenges common to multiple arenas: linking science to decision making and linking science and decision making across multiple levels. The U.S. agricultural research, education, and extension system was designed to address these challenges. By investigating this system, this study deepens the understanding of science and decision making, specifically exploring the notion of boundary organizations in two significant ways. First, it provides a preliminary test of the hypothesis that boundary organizations mediate between the shifting (...) domains of science and policy, finding that they are instrumental in creating and maintaining an integrated system of assessment and decision making for addressing depletion of the High Plains Aquifer. Second, it extends the concept of boundary organization beyond the science-policy dimension to incorporate the dimension of levels of organization—not only bridging science and policy but linking science and policy across different levels. (shrink)

If we want to see justice done with regard to responsibility, then we must either (i) allow that people are never morally responsible, (iia) show that luck is not ubiquitous or at least that (iib) ubiquitous luck is not moral, or (iii) show that ascriptions of responsibility can retain justice despite the omnipresence of luck. This paper defends (iii); ascriptions of responsibility can be just even though luck is ubiquitous.

Within political theory there has been a recent surge of interest in the themes of loss, grief, and mourning. In this paper i address questions about the politics of mourning through a critical engagement of the work of Judith Butler. I argue that Butler's work remains tethered to an account of melancholic subjectivity derived from her early reading of Freud. These investments in melancholia compromise Butler's recent ethico-political interventions by obscuring the ambivalence of political engagements and the possibilities of achieving (...) and sustaining non-dogmatic identities. To overcome this impasse I argue for an alternative framing of mourning by turning to the psychoanalytic theory of Melanie Klein. An account of mourning that leans upon Klein's work cashes in on the ethical and political promises that are immanent yet unrealized in Butler's recent work while providing a new orientation for mourning in, and for, democratic politics. (shrink)

This article examines Engelhardt’s thesis from the standpoint of liturgical theology. Fagerberg’s previous work has claimed that liturgy gives birth to theology in such a way that liturgy is the ontological condition for theology, as Schmemann said. If we apply this approach to the question at hand, we will understand liturgy to be the source and foundation also for Christian morality. This is no particular surprise, since the Christian tradition has always integrated liturgy, theology, and asceticism, that last named treating (...) morality as a pathway to deification. Liturgical theology views liturgy as a pneumatic exercise that makes theologian souls, and liturgical asceticism understands such theologian souls to be molded by the doings of the body, and this delivers us to the threshold of liturgical morality, for in liturgy the God’s-eye perspective shares its light with us. (shrink)

Hannah Arendt's existential, republican concept of politics spurned Carl Schmitt's idea that enmity constituted the essence of the political. Famously, she isolated the political sphere from social conflict, sovereign regimes, and the realm of military violence. While some critics are now interested in applying Arendt's more abstract political ideas to international affairs, it has not been acknowledged that her original reconceptualization of politics was in fact driven by her analysis of global war, and in particular, the startling new challenges raised (...) by nuclear warfare. Arendt's early, unpublished manuscript on the nature of politics contains important reflections on the nature of war and empire. Surprisingly, these reflections tentatively explore the relationship between war and political freedom. A close reading of this work on war can help explain both her later, more radical non-violent concept of political action, and the difficulties she faced integrating her existential republicanism within the global context of conflict in the Cold War. (shrink)

Two experiments using a realistic version of the selection task examined the relationship between participants' probability estimates of finding a counter example and their selections. Experiment 1 used everyday categories in the context of a scenario to determine whether or not the number of instances in a category affected the estimated probability of a counter-example. Experiment 2 modified the scenario in order to alter participants' estimates of finding a specific counter-example. Unlike Kirby 1994a, but consistent with his proposals, both studies (...) showed that probability estimates significantly predicted selection. Overall results point to the value of understanding selections in terms of their subjective expected utility. (shrink)